[Hormonal status in patients with Mayer-Rokitansky-Küster syndrome]

A characteristic and comparatively frequent malformation of the female genital tract is the congenital absence of the vagina and a rudimentary uterus, known as Mayer-Rokitansky-Küster syndrome. Since we employ the modified surgical technique according to Vecchetti we have a relatively large incidence of patients with this syndrome. Thus, a total of 15 patients were hospitalised for a thorough endocrinological examination including a GnRH test with 2 bolus injections of GnRH, TRH-test, the determination of testosterone, DHEAS, androstendione and gonadotropin as well as prolactin fluctuation over a 4-hour period. The values of 4 patients without any endocrinological disorder served as control group. 2 of the 15 patients showed an increase in androgenic hormones; 8 patients a slight hyperprolactinaemia disclosed by the TRH test. The gonadotropin fluctuation in all patients was restricted and the stimulation of the pituitary gland with GnRH bolus injections was diminished. The naloxone test led to a significant increase in peripheral gonadotropins. It remains to be determined whether this endocrinological disorder is the cause or the outcome of the rudimentary inner genitals.