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Updated: Nov 11, 2025
08:32
Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
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Insulin as a neuroendocrine hormone
David R Grattan1, Zane B Andrews2
1Centre for Neuroendocrinology, University of Otago, Dunedin, New Zealand.
Journal of Neuroendocrinology
|March 31, 2021
Summary
Insulin, discovered 100 years ago, is crucial for diabetes treatment. Recent research reveals its vital roles in brain function, impacting obesity and dementia, offering new health insights.
Area of Science:
- Neuroendocrinology
- Biomedical Research
Background:
- The Special Issue commemorates 100 years since insulin's discovery, a landmark in diabetes treatment.
- Insulin's critical role in treating diabetes mellitus is a major biomedical success story.
Discussion:
- Emerging evidence highlights insulin's diverse and significant actions within the brain.
- These brain-related insulin functions are increasingly recognized for their importance in neuroendocrine regulation.
Key Insights:
- Insulin influences brain functions relevant to conditions like obesity and dementia.
- Understanding central insulin action is key to neuroendocrine research.
Outlook:
- Further research into brain insulin signaling promises advancements in treating metabolic and neurodegenerative diseases.
- This Special Issue explores current knowledge and future directions in brain insulin research.
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