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Related Experiment Video

Updated: Nov 11, 2025

Whole-brain Segmentation and Change-point Analysis of Anatomical Brain MRI—Application in Premanifest Huntington's Disease
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Quantifying progression in primary progressive aphasia with structural neuroimaging.

Jolina Lombardi1, Benjamin Mayer2, Elisa Semler1

  • 1Department of Neurology, University Hospital Ulm, Ulm, Germany.

Alzheimer'S & Dementia : the Journal of the Alzheimer'S Association
|March 31, 2021
PubMed
Summary
This summary is machine-generated.

Primary progressive aphasia (PPA) involves significant brain atrophy at baseline, varying by subtype. Magnetic resonance imaging volumetry helps track this disease progression for therapeutic trial development.

Keywords:
atlas-based volumetrydisease progressionfrontotemporal dementialongitudinal magnetic resonance imagingprimary progressive aphasiasample size calculation

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Area of Science:

  • Neuroimaging
  • Neurology
  • Cognitive Science

Background:

  • Primary progressive aphasia (PPA) encompasses non-fluent (nfvPPA), semantic (svPPA), and logopenic (lvPPA) variants.
  • Limited magnetic resonance imaging (MRI) volumetry data exists for monitoring PPA progression.

Purpose of the Study:

  • To assess longitudinal brain atrophy patterns in PPA variants using MRI volumetry.
  • To provide data for calculating sample sizes in future therapeutic trials for PPA.

Main Methods:

  • Structural MRI and comprehensive assessments were conducted on 269 participants over 4 years.
  • Automated atlas-based volumetry was used to analyze 56 brain regions.
  • Atrophy progression rates were calculated to inform trial design.

Main Results:

  • Baseline atrophy was most pronounced in the left frontal lobe (nfvPPA), left temporal lobe (svPPA), and left temporal regions (lvPPA).
  • One-year follow-up showed the most rapid progression in the basal ganglia (nfvPPA), hippocampus/amygdala (svPPA), and medial temporal regions (lvPPA).

Conclusions:

  • PPA is a left-dominant, gray matter disease characterized by significant baseline atrophy.
  • Atrophy progression is specific to each PPA variant, highlighting the need for variant-tailored monitoring and treatment.