Related Experiment Video

Updated: Nov 11, 2025

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy
09:18

Measurements of Motor Function and Other Clinical Outcome Parameters in Ambulant Children with Duchenne Muscular Dystrophy

Published on: January 12, 2019

10.6K

Parent-Reported Medication Side Effects and Their Impact on Health-Related Quality of Life in Children With Juvenile

Gaëlle Chédeville1, Katherine McGuire2, David A Cabral3

  • 1McGill University, Montreal, Quebec, Canada.

Arthritis Care & Research
|March 31, 2021
PubMed

Insights

Two-thirds of children with juvenile idiopathic arthritis (JIA) experience medication side effects (SEs) impacting their quality of life within a year. New strategies are needed to manage these SEs in JIA patients.

Area of Science:

  • Pediatric Rheumatology
  • Pharmacovigilance
  • Health-Related Quality of Life

Background:

  • Juvenile idiopathic arthritis (JIA) is a chronic condition requiring long-term medication.
  • Understanding medication side effects (SEs) and their impact on health-related quality of life (HRQoL) is crucial for effective JIA management.
  • Parental reporting of SEs offers valuable insights into the patient experience.

Purpose of the Study:

  • To determine the frequency and severity of parent-reported medication SEs in children with JIA.
  • To compare parent-reported SEs with physician-reported actionable adverse events (AEs).
  • To evaluate the impact of SEs on the HRQoL of children with JIA.

Main Methods:

  • A prospective study of newly diagnosed JIA patients from the Canadian Alliance of Pediatric Rheumatology Investigators (CAPRI) Registry (2017-2019).
  • Parents reported SE presence and severity; physicians reported actionable AEs at clinic visits.
  • HRQoL assessed using the Quality of My Life (QoML) questionnaire and parent's global assessment.

Main Results:

  • SEs were reported at 42% of visits, with a median of 2 SEs per visit and severity of 3.
  • Gastrointestinal and behavioral/psychiatric SEs were most common.
  • Cumulative incidence of SEs was 67% within 1 year, compared to 36% for actionable AEs; SEs negatively impacted HRQoL.

Conclusions:

  • Parents report significant medication side effects in two-thirds of children with JIA within the first year of diagnosis.
  • These SEs demonstrably impact children's health-related quality of life.
  • Development and implementation of SE mitigation strategies are essential for optimal JIA management.
Abstract

More Related Videos

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients02:28

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients

Published on: March 1, 2024

597
Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain04:50

Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain

Published on: May 16, 2025

518

Related Concept Videos

Therapeutic Drug Monitoring: Affecting Factors01:29

Therapeutic Drug Monitoring: Affecting Factors

Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
57
Pharmacovigilance01:19

Pharmacovigilance

Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.4K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
76
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
80
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
109
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
82