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The Le(a+b+) phenotype in Polynesians.

S M Henry1, L A Simpson, D G Woodfield

  • 1Department of Transfusion Medicine, Auckland Regional Blood Centre, Auckland Hospital, New Zealand.

Human Heredity
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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The rare Lewis phenotype Le(a+b+) was found in Polynesian populations, with higher frequency in blood group 0 individuals. This blood group antigen

Area of Science:

  • * Human genetics
  • * Population genetics
  • * Immunogenetics

Background:

  • * The Lewis blood group system is important in transfusion medicine and population studies.
  • * The Le(a+b+) phenotype is rare and its distribution in different ethnic groups is of scientific interest.

Purpose of the Study:

  • * To investigate the prevalence of the Lewis phenotype Le(a+b+) in Polynesian populations.
  • * To explore associations between this phenotype and blood groups, age, sex, and H reactivity.

Main Methods:

  • * Phenotypic analysis of Lewis antigens (Le(a) and Le(b)) in blood samples.
  • * Statistical analysis to determine frequencies and associations.

Main Results:

  • * The Le(a+b+) phenotype was detected in Maori, Samoan, Cook Islander, Nuiean, and Tokelau Islander groups.

Related Experiment Videos

  • * The phenotype occurred across all ABO blood groups but was significantly more frequent in individuals with blood group 0.
  • * No significant association was found with H reactivity in blood group A donors, nor with age or sex.

    • Conclusions:

    • * The Le(a+b+) phenotype is present in various Polynesian populations.
    • * Blood group 0 is a significant factor associated with increased frequency of the Le(a+b+) phenotype in these populations.
    • * The phenotype's distribution is independent of age, sex, and H reactivity in group A donors within this study cohort.