Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Autoimmunity and its therapy: mathematical modelling.

J Waniewski1, D Prikrylová

  • 1Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Warsaw.

Immunology Letters
|May 1, 1988
PubMed
Summary

This study presents a mathematical model for understanding the origins and progression of autoimmune diseases. It incorporates clonal deletion and T-helper cell stimulation to explore potential therapeutic strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mathematical modeling of peritoneal buffer transport and acidosis correction in patients on peritoneal dialysis.

Scientific reports·2026
Same author

Relative blood volume changes during haemodialysis estimated from haemoconcentration markers.

Scientific reports·2020
Same author

Phenotypic features of vascular calcification in chronic kidney disease.

Journal of internal medicine·2019
Same author

Comparison of three PET methods to assess peritoneal membrane transport.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2019
Same author

The Valsalva manoeuvre: physiology and clinical examples.

Acta physiologica (Oxford, England)·2015
Same author

Comparison of kinetic characteristics of amino acid-based and dipeptide-based peritoneal dialysis solutions.

The International journal of artificial organs·2006

Area of Science:

  • Immunology
  • Mathematical Biology
  • Computational Medicine

Background:

  • Autotolerance is crucial for preventing immune system attacks against self-antigens.
  • Dysregulation of immune responses can lead to autoimmune diseases.
  • Existing models of immune response require expansion to encompass autoimmunity.

Purpose of the Study:

  • To develop a mathematical framework describing autotolerance and autoimmunity.
  • To integrate key immunological theories, including clonal deletion and T-helper cell activation, into the model.
  • To provide insights into the origins and qualitative progression of autoimmune conditions.

Main Methods:

  • Mathematical modeling based on established immune response principles.
  • Inclusion of clonal deletion theory to represent self-reactive lymphocyte elimination.
  • Incorporation of non-specific T-helper cell stimulation as a potential trigger for autoimmunity.

Main Results:

  • The model provides a quantitative description of the balance between self-tolerance and autoimmune attack.
  • It elucidates how disruptions in clonal deletion or T-helper cell regulation can initiate autoimmune processes.
  • The model offers a qualitative understanding of the dynamic course of autoimmune diseases.

Conclusions:

  • Mathematical modeling offers valuable insights into the complex mechanisms underlying autoimmunity.
  • The presented model supports the understanding of autoimmune disease origins and progression.
  • It provides a basis for discussing and evaluating potential therapeutic interventions like immunosuppression and autoantibody removal.

Related Experiment Videos