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Updated: Nov 10, 2025

Author Spotlight: Advancing Cancer Associated Thrombosis Research in Rodent Models
Published on: January 5, 2024
Risk Factors for Venous Thromboembolism in Patients With Small Cell Lung Cancer
Evangelos Dimakakos1, Konstantinos Livanios2, Ioannis Vathiotis2
1Oncology Unit, 3 Department of Medicine, "Sotiria" General Hospital, Schoolof Medicine, National and Kapodistrian University of Athens, Athens, Greece edimakakos@yahoo.gr.
Background/Aim:
Small cell lung cancer (SCLC) accounts for 13% of all lung cancers. Venous thromboembolism (VTE) is a frequent complication. The purpose of this study was to investigate the incidence and risk factors for VTE in SCLC patients.
Patients And Methods:
Retrospective analysis of patients with histologically confirmed SCLC treated between January 2015 and June 2018 at Sotiria General Hospital, Athens, Greece.
Results:
Two hundred and seventeen patients were included in the analysis. The incidence of VTE was 4.1%. Increased body mass index (BMI) was correlated with the development of VTE. Moreover, VTE appeared more frequently in patients with major vessel infiltration and with poor Eastern Cooperative Oncology Group Performance Status. Other factors, including gender, age, stage, presence of metastasis, treatment, immobilization, anticoagulation, comorbidities, and laboratory values did not correlate with the development of VTE.
Conclusion:
Factors associated with the development of VTE were BMI, major vessel infiltration and PS. Identifying factors that predispose to VTE could help physicians detect high-risk patients who would benefit from prophylactic anticoagulation therapy.
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