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Updated: Nov 10, 2025

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Site-specific Response to Nivolumab in Renal Cell Carcinoma
Takahito Negishi1, Nobuki Furubayashi2, Tohru Nakagawa3
1Department of Urology, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan; n2takajin@gmail.com.
Background/Aim:
Nivolumab monotherapy for advanced/metastatic renal cell carcinoma (RCC) shows a survival benefit. The purpose of this study was to evaluate tumor responses to nivolumab in various metastatic and primary sites in patients with RCC.
Patients And Methods:
We retrospectively reviewed 68 patients who underwent nivolumab monotherapy after one or more regimens of targeted therapy for advanced/metastatic RCC. The site-specific response was evaluated and progression-free survival was estimated.
Results:
The site-specific overall response rates (ORRs) were as follows: lung (36%), bone (5%), lymph node (33%), liver (50%), adrenal gland (29%), pancreas (33%), and brain (0%). The ORR of bone metastasis was significantly worse in comparison to lung and liver metastases (p=0.017, 0.008). The site-specific median progression-free survival times were as follows: lung (5.1 months), bone (not reached), lymph node (not reached), and liver (17.5 months).
Conclusion:
Responses to nivolumab may vary depending on metastasized organs.
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