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A Novel Method: Super-selective Adrenal Venous Sampling
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Normal and Premature Adrenarche.

Robert L Rosenfield1,2

  • 1University of Chicago Pritzker School of Medicine, Section of Adult and Pediatric Endocrinology, Metabolism, and Diabetes, Chicago, IL, USA.

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|March 31, 2021
PubMed
Summary
This summary is machine-generated.

Adrenarche, the rise in adrenal androgens, is crucial for puberty onset. Premature adrenarche often causes early pubic hair development and may increase risks for obesity and insulin resistance.

Keywords:
adrenal androgensadrenarchepolycystic ovary syndromepubarchesteroidogenic enzyme expressionzona reticularis

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Area of Science:

  • Endocrinology
  • Developmental Biology
  • Molecular Genetics

Background:

  • Adrenarche is the maturational increase in adrenal androgen production, beginning in early childhood.
  • This process is linked to the development of the zona reticularis (ZR) and specific gene/enzyme expression.
  • Adrenarchal androgens contribute to pubic hair and gland development.

Purpose of the Study:

  • To review recent advances in understanding adrenarche and zona reticularis development.
  • To explore the molecular genetic and developmental biologic insights into adrenarche.
  • To discuss the role of mass spectrometric steroid assays in adrenarche research.

Main Methods:

  • Review of recent scientific literature on adrenarche.
  • Analysis of molecular genetic and developmental biologic factors influencing the zona reticularis.
  • Integration of findings from mass spectrometric steroid assays.

Main Results:

  • Adrenarche involves changes in ACTH response, indexed by DHEAS rise, and ZR development.
  • 11-ketotestosterone identified as a key bioactive adrenarchal androgen.
  • Premature adrenarche is the primary cause of premature pubarche, with associated health risks.

Conclusions:

  • Understanding ZR development and adrenarche is advancing through molecular and mass spectrometry techniques.
  • Premature adrenarche, while common, requires differential diagnosis from other virilizing disorders.
  • Further research is needed to fully elucidate the causes and long-term implications of premature adrenarche.