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Dynamic interplay between cell membrane tension and clathrin-mediated endocytosis
Umidahan Djakbarova1, Yasaman Madraki1, Emily T Chan2,3
1Department of Physics, The Ohio State University, Columbus, OH, 43210, USA.
Biology of the Cell
|March 31, 2021
Summary
Cell membrane tension, a key factor in cell flexibility, dynamically regulates clathrin-mediated endocytosis (CME). This review explores how membrane tension influences CME processes and clathrin coat formation.
Area of Science:
- Cell Biology
- Biophysics
- Mechanobiology
Background:
- The plasma membrane's deformability is crucial for cellular functions like motility and endocytosis.
- Membrane tension influences various cellular processes, including vesicle trafficking.
Purpose of the Study:
- To review the mechanoregulation of clathrin-mediated endocytosis (CME).
- To explore the role of cell membrane tension in regulating CME.
Main Methods:
- Literature review of recent studies on membrane tension and CME.
- Analysis of factors affecting cell membrane tension dynamics.
- Discussion of tension-based regulation of endocytic clathrin coat assembly.
Main Results:
- Cell membrane tension is a significant regulator of CME.
- Membrane tension acts as a fast-acting and reversible regulator of endocytosis.
- Tension influences the formation of the endocytic clathrin coat.
Conclusions:
- Cell membrane tension is a critical mechanoregulator of clathrin-mediated endocytosis.
- Understanding membrane tension dynamics provides insights into cellular flexibility and endocytic processes.
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