A Base-Mediated Approach Towards Dihydrofuro[2,3-b]Benzofurans from 2-Nitrobenzofurans and 1,3-Dicarbonyls
Gurdeep Singh1, Rajat Pandey1, Adarsh S Kurup1
1Department of Chemical Sciences, Indian Institute of Science Education and Research (IISER) Mohali, Sector 81, S. A. S. Nagar, Manauli (PO), Punjab, 140306, India.
Abstract:
A straight-forward approach for the synthesis of a dihydrofuro[2,3-b]benzofuran derivatives has been achieved through a base-mediated Michael addition of 1,3-dicarbonyls to 2-nitrobenzofurans followed by intramolecular cyclization. A variety of 1,3-dicarbonyls, including cyclic as well as trifluoromethylated ones, have been subjected to react with 2-nitrobenzofurans under optimal conditions, and the respective dihydrofuro[2,3-b]benzofurans could be accessed in moderate to excellent yields.
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