Distal snuffbox versus conventional radial artery access: An updated systematic review and meta-analysis
Related Experiment Video
Updated: Nov 10, 2025

Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
Published on: September 20, 2020
Gianluca Rigatelli1, Marco Zuin2,3, Ramesh Daggubati4
1Cardiovascular Diagnosis and Endoluminal Interventions Unit, Rovigo General Hospital, Rovigo, Italy.
Insights
Distal transradial access significantly reduces the risk of radial artery occlusion compared to conventional transradial access. This meta-analysis found no significant differences in hematoma or spasm rates between the two approaches.
Area of Science:
- Cardiovascular Interventions
- Vascular Access Techniques
- Interventional Cardiology
Background:
- Transradial access is a common approach for coronary angiography and percutaneous coronary interventions.
- Vascular complications remain a concern, with ongoing research into optimizing access sites.
- A clear benefit of distal transradial access over conventional methods regarding complications is yet to be definitively established.
Purpose of the Study:
- To conduct a systematic review and meta-analysis comparing vascular complications between distal and conventional transradial access.
- To provide an updated comparison of outcomes for coronary angiography and/or percutaneous coronary intervention.
- To evaluate the safety and efficacy of distal versus conventional transradial access.
Main Methods:
- Systematic review and meta-analysis of case-control studies.
- Searched MEDLINE, Scopus, and Web of Science for relevant literature up to December 22, 2020.
- Primary outcome: radial artery occlusion; Secondary outcomes: hematoma and spasm.
Main Results:
- Analyzed data from 7073 patients across eight studies.
- Significantly lower rate of radial artery occlusion with distal access (2.1%) compared to conventional access (4.6%).
- No significant differences observed in hematoma or radial artery spasm rates between the groups.
Conclusions:
- Distal transradial access is associated with a reduced risk of radial artery occlusion.
- The safety profile regarding hematoma and spasm is comparable between distal and conventional transradial access.
- Distal transradial access may offer advantages in reducing vascular complications during cardiac procedures.
Background:
A comprehensive comparison of available data in terms of vascular complications between distal and conventional transradial access is still partial and a net benefit of such approach has not yet been clearly demonstrated.
Objective:
To provide an updated comparison of complications between distal and conventional transradial access used to perform coronary angiography and/or percutaneous coronary intervention performing a systematic review and meta-analysis.
Data Sources:
Data were obtained searching MEDLINE, Scopus, and Web of Science for all investigations published any time to December 22, 2020 reporting a comparison between distal and conventional transradial access. The occurrence of radial artery occlusion was chosen as the primary outcome while the hematoma at access site and spasm as secondary and tertiary outcome, respectively.
Study Eligibility Criteria:
Case-control studies comparing distal and conventional transradial access for coronary angiography and/or percutaneous coronary intervention. All studies included adult patients aged at least 18 years.
Study Appraisal And Synthesis Methods:
Overall, 7073 patients (mean age 57.9 and 58.4 years for distal and conventional transradial access, respectively), were analyzed. The rate of radial artery occlusion was significantly lower in the distal compared with the conventional group (2.1% vs 4.6%, p < 0.001). The pooled analysis, based on a fixed effect model confirmed a lower relative risk of occlusion when distal access is used (RR: 0.46, 95% CI: 0.31-069, p = 0.002, I2 = 0%). Conversely, no differences in the risk of developing a hematoma at the access site or in the occurrence of a radial artery spasms were observed comparing the two groups (RR: 0.65, 95% CI: 0.37-1.13, p = 0.12, I2 = 0% and RR: 0.88, 95% CI: 0.48-1.63, p = 0.001, I2 = 0%, respectively).
Limitations:
Only eight case-control studies met inclusion criteria.
Conclusion:
This metanalysis confirmed a lower risk of radial artery occlusion using distal access and comparable performance in terms of hematoma, and radial artery spam risk.
Related Concept Videos
Assessment of radial pulse
The radial pulse, located at the wrist, is often the preferred site for assessing peripheral pulse because of its accessibility and dependability. The process of determining the radial pulse involves several steps:
Assessment of apical radial pulse
The A-R pulse assessment involves simultaneous evaluation of the apical and radial pulses. When the apical and radial pulse rates vary, this assessment helps identify a pulse deficit.
Pre-Procedural Preparation
Sites for measruring blood pressure
The Brachial Artery: Primary Site for Blood Pressure Measurement
Arteries of the Upper Limbs
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

