Related Experiment Video

Updated: Nov 10, 2025

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

6.1K

Intranasal leptin improves survival after opioid overdose in a mouse model

Carla Freire1,2, Huy Pho3, Shannon Bevans-Fonti3

  • 1Johns Hopkins Sleep Disorders Center, 5501 Hopkins Bayview Circle, room 5A.50, Baltimore, MD, 21224, USA. cfreire2@jhmi.edu.

Journal of Translational Medicine
|April 1, 2021
PubMed
Summary

No abstract available in PubMed .

Keywords:
Blood brain barrierLeptinOpioid overdoseOpioid reversal agents

More Related Videos

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
09:54

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence

Published on: March 8, 2020

5.4K
White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice
06:16

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice

Published on: September 9, 2025

239

Related Experiment Videos

Last Updated: Nov 10, 2025

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing
05:45

Experimental Approach to Examine Leptin Signaling in the Carotid Bodies and its Effects on Control of Breathing

Published on: October 25, 2019

6.1K
Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence
09:54

Combining Laser Capture Microdissection and Microfluidic qPCR to Analyze Transcriptional Profiles of Single Cells: A Systems Biology Approach to Opioid Dependence

Published on: March 8, 2020

5.4K
White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice
06:16

White and Brown Adipose Grafts: An Approach to Correct Reproductive, Metabolic, and Renal Deficits in Black and Tan Brachyury (BTBR) Obese Mice

Published on: September 9, 2025

239

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

632
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
632

Articles linked to this work by shared authors, journal, and citation graph.

DPP9-mediated inflammasome repression protects against checkpoint inhibitor lung toxicity.

bioRxiv : the preprint server for biology·2026

Leptin alleviates obesity hypoventilation via serotonergic pathways.

bioRxiv : the preprint server for biology·2026

Sex Differences in the Sleep Architecture and Sleep-Disordered Breathing in C57BL/6 J Mice.

Sleep·2026

Oxytocin attenuates respiratory depression and reduces mortality from fentanyl and the combination of xylazine-fentanyl in rats.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026

Melanocortin receptor 4 agonist setmelanotide treats opioid-induced respiratory depression.

bioRxiv : the preprint server for biology·2026

Melanocortin 4 receptor signalling in sleep-disordered breathing.

The Journal of physiology·2026

Epigenetic dysregulation in depression: molecular mechanisms, clinical biomarkers, and therapeutic opportunities.

Journal of translational medicine·2026

Longitudinal profiling of upper respiratory tract microbiota and metabolome in hospitalized COVID-19 convalescents: a 3-year prospective cohort study.

Journal of translational medicine·2026

Circ17399 RNA promotes melanoma progression through the miR-150-3p/ITM2C Axis and ALKBH5-mediated FOXM1 m6A modification.

Journal of translational medicine·2026

Efficacy and safety of AAV RPGR gene therapy in X-linked retinitis pigmentosa: a systematic review and meta-analysis.

Journal of translational medicine·2026

IL-17 Receptor inhibition with brodalumab limits experimental periodontitis.

Journal of translational medicine·2026

Targeting the IL-17C-M2 macrophage axis ameliorates fibrosis in endometriosis through MAPK/ERK signaling.

Journal of translational medicine·2026

The diagnostic and prognostic role of miRNA-21 and miRNA-223 in laryngeal squamous cell carcinoma: A systematic review with exploratory meta-analysis.

The Medical journal of Malaysia·2026

The impact of lymphovascular space invasion on recurrence and survival rate among women with stage I endometrioid endometrial cancer.

The Medical journal of Malaysia·2026

Cardiac Remodeling Trajectory and Renal Stage-Specific Risk Stratification in East Asian Fabry Disease Patients.

JACC. Asia·2026

Cost-Effectiveness Analysis of Fecal Immunochemical Test-based Versus Total Colonoscopy-Based Colorectal Cancer Screening in Japan: A Microsimulation Study.

Value in health regional issues·2026

Prognostic Value of Systemic Inflammatory Markers in Predicting Peritoneal Metastasis in Gastric and Gastroesophageal Junction Cancer.

Clinical and translational science·2026

A radiomic approach to non-invasively decode tumor immune microenvironmental features in surgically resected non-small cell lung cancer.

Tumori·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us