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A Substantial Response from Adding Palbociclib to Endocrine Therapy in Brain Metastasis from Hormone
Atlal Abusanad1, Hashem Al Hashem2
1Division of Medical Oncology, Internal Medicine Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.
Abstract:
Brain metastasis (BM) from breast cancer has poor prognosis despite new advances and multi-modality treatments. No current data is guiding the use of palbociclib in the management of hormone receptor (HR)-positive breast cancer patients with BM as these patients were excluded systematically from all phase 3 trials. Here, we report an evident clinical response from combining palbociclib with endocrine therapy in HR-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer with BM.
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