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The Future of Blood Testing Is the Immunome
Ramy A Arnaout1,2, Eline T Luning Prak3, Nicholas Schwab4
1Department of Pathology and Division of Clinical Informatics, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, United States.
Frontiers in Immunology
|April 1, 2021
Summary
The immunome, encompassing antibody and T cell receptor gene signatures, offers a novel approach for personalized medicine. Analyzing these immune profiles can lead to a universal blood test for various diseases.
Area of Science:
- Immunology
- Genomics
- Personalized Medicine
Background:
- Clinically significant conditions like infections, autoimmune diseases, and cancers leave detectable signatures in immune system genes.
- The adaptive immune receptor repertoire, termed the immunome, comprises millions of V(D)J-rearranged antibody and T cell receptor (TCR) genes.
Purpose of the Study:
- To explore the diagnostic potential of the immunome for personalized medicine.
- To discuss the current state and challenges of immunome-based diagnostics.
Main Methods:
- Analysis of V(D)J-rearranged antibody and T cell receptor (TCR) gene sequences.
- Leveraging the immunome as a substrate for a multiplexed blood test.
Main Results:
- The immunome's diversity and complexity present unique opportunities for diagnostics.
- Immunome-based approaches can serve as a foundation for near-universal blood tests.
Conclusions:
- The immunome holds significant promise for advancing personalized medicine through novel diagnostic tools.
- Collaboration through initiatives like the Adaptive Immune Receptor Repertoire Community (AIRR-C) is crucial to realize the immunome's diagnostic potential.
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