Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bode Plots Construction01:24

Bode Plots Construction

909
The Bode plot is an essential tool in control system analysis, mapping the frequency response of a system through a magnitude plot and a phase plot, both against a logarithmic frequency axis. To construct a Bode plot, consider the transfer function H(ω):
909
Electrostatic Boundary Conditions01:16

Electrostatic Boundary Conditions

735
Consider an external electric field propagating through a homogeneous medium. When the electric field crosses the surface boundary of the medium, it undergoes a discontinuity. The electric field can be resolved into normal and tangential components. The amount by which the field changes at any boundary is given by the difference between the field components above and below the surface boundary.
The surface integral of an electric field is given by Gauss's law in integral form and is related to...
735
Electrostatic Boundary Conditions in Dielectrics01:27

Electrostatic Boundary Conditions in Dielectrics

1.5K
When an electric field passes from one homogeneous medium to another, crossing the boundary between the two mediums imparts a discontinuity in the electric field. This results in electrostatic boundary conditions that depend on the type of mediums the field propagates through.
Consider a case where both the mediums across a boundary are two different dielectric materials. Recall that the electric field and electric displacement are proportional and related through the material's permittivity....
1.5K
Boundary Conditions for Current Density01:25

Boundary Conditions for Current Density

1.1K
Current density becomes discontinuous across an interface of materials with different electrical conductivities. The normal component of the current density is continuous across the boundary.
1.1K
Boundary Conditions: Lossless Lines01:21

Boundary Conditions: Lossless Lines

200
Consider a single-phase, two-wire, lossless transmission line terminated by an impedance at the receiving end and a source with Thevenin voltage and impedance at the sending end. The line, with length, has a surge impedance and wave velocity determined by the line's inductance and capacitance.
At the receiving end, the boundary condition states that the voltage equals the product of the receiving-end impedance and current. This relationship is expressed as a function of the incident and...
200
Equipotential Surfaces and Conductors01:16

Equipotential Surfaces and Conductors

4.0K
For a conductor in which all charges are at rest, the conductor's surface is equipotential. The electric field is always perpendicular to equipotential surfaces. Therefore, in a conductor with static charges, the electric field just outside the conductor is always perpendicular to the conductor's surface. Any tangential component of the electric field will cause charges to move inside the conductor, which will violate the electrostatic nature of the system. In an electrostatic...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reply: Stem cell-based embryo models: scientific promise clashes with ethical reality.

Human reproduction (Oxford, England)·2026
Same author

Identifiability limits and deep-learning-assisted reconstruction of rotational density matrices for symmetric-top molecules.

The Journal of chemical physics·2026
Same author

Type I interferon primes the alveolar epithelium to receive reparative signals from tissue-resident macrophages.

bioRxiv : the preprint server for biology·2026
Same author

Voltage dynamics of cortical dendrites in vivo.

Nature neuroscience·2026
Same author

Molecular magnetic X-ray scattering with ultrashort X-ray free-electron lasers: from spin-orbit dynamics to Berry phase detection.

Physical chemistry chemical physics : PCCP·2026
Same author

Author Correction: In vitro characterization of the human segmentation clock.

Nature·2026

Related Experiment Video

Updated: Nov 10, 2025

Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device
11:08

Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device

Published on: September 19, 2025

724

Bioelectrical domain walls in homogeneous tissues.

Harold M McNamara1,2, Rajath Salegame3, Ziad Al Tanoury4,5

  • 1Department of Physics, Harvard University.

Nature Physics
|April 1, 2021
PubMed
Summary

Homogeneous tissues can spontaneously form distinct electrical domains separated by stable walls. These bioelectrical domain walls can migrate, revealing a novel mechanism for electrical signaling in biological systems.

More Related Videos

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts
08:33

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Published on: July 18, 2025

533
Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance
10:51

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Published on: September 26, 2017

16.6K

Related Experiment Videos

Last Updated: Nov 10, 2025

Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device
11:08

Revealing Electromechanical Control of Tissue Homeostasis Using a Two-Layer Microfluidic Device

Published on: September 19, 2025

724
Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts
08:33

Bidirectional Electrical and Optoelectronic Interfaces in Healthy and Ischemic Ex Vivo Rat Hearts

Published on: July 18, 2025

533
Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance
10:51

Fabrication and Validation of an Organ-on-chip System with Integrated Electrodes to Directly Quantify Transendothelial Electrical Resistance

Published on: September 26, 2017

16.6K

Area of Science:

  • Electrophysiology
  • Systems Biology
  • Cell Biology

Background:

  • Electrical signaling in biology is primarily understood through action potentials.
  • Existing models like Hodgkin-Huxley describe transient voltage spikes.
  • Reaction-diffusion equations theoretically allow for stable spatial patterns in membrane voltage.

Purpose of the Study:

  • To investigate the spontaneous emergence of spatial patterns in membrane voltage within homogeneous tissues.
  • To identify purely electrophysiological mechanisms driving spatial symmetry breaking.
  • To characterize the formation and dynamics of bioelectrical domain walls.

Main Methods:

  • Theoretical modeling using reaction-diffusion equations.
  • Experimental validation using all-optical electrophysiology.
  • Utilizing engineered cell lines and human induced pluripotent stem cell (iPSC)-derived myoblasts.

Main Results:

  • Demonstrated spontaneous spatial symmetry breaking in nominally homogeneous tissues.
  • Observed the formation of distinct domains with different resting potentials.
  • Mapped the long-range migration of stable bioelectrical domain walls.

Conclusions:

  • Homogeneous tissues can exhibit complex electrical organization through intrinsic electrophysiological mechanisms.
  • Bioelectrical domain wall dynamics represent a novel form of biological signaling.
  • This mechanism may play a role in embryonic development and polarized tissue function.