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Published on: January 12, 2017
Integrin Alpha V in Urine: A Novel Noninvasive Marker for Prostate Cancer Detection
Marina Y Zemskova1,2, Maria V Marinets3, Andrey V Sivkov3
1G.K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Federal Research Center, Pushchino Center for Biological Research of the Russian Academy of Sciences, Pushchino, Russia.
Abstract:
Prostate cancer (PCa) diagnosis based on patient urine analysis provides non-invasive and promising method as compared to biopsy and a prostate-specific antigen (PSA) test. This study was conceived to investigate whether Integrin alpha V (ITGAV) protein is present in urine and assess the urinary ITGAV diagnostic potential for PCa.
Materials And Methods:
Urinary ITGAV expression was determined by Western blot analysis and quantified by ELISA in urine from men with PCa (n = 47), benign prostate hyperplasia (n = 42) and age-matched controls (n = 22).
Results:
The level of ITGAV protein was significantly lower in PCa urine samples as compared to those in the control group (p < 0.00001). The decrease of ITGAV in urine was highly predictive of PCa with 91.5% sensitivity, 91.4% specificity, 0.93 area under the ROC curve, and its specificity was better than that of serum PSA.
Conclusion:
Urinary ITGAV provides a novel noninvasive biomarker with high specificity.
