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Cardiovascular Disease and COVID-19: Insight From Cases With Heart Failure

Yang Yi1, Yanan Xu2, Haibing Jiang1

  • 1Department of Cardiology Fourth Ward, Xinjiang Medical University Affiliated Hospital of Traditional Chinese Medicine, Urumqi, China.

Frontiers in Cardiovascular Medicine
|April 1, 2021
PubMed

Insights

Coronavirus disease 2019 (COVID-19) significantly increases heart failure risk due to cardiovascular complications. This review explores COVID-19-related heart failure mechanisms and treatment strategies.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Pharmacology

Background:

  • A substantial portion of coronavirus disease 2019 (COVID-19) mortality is linked to cardiovascular complications, including myocardial infarction, arrhythmias, and heart failure.
  • Severe COVID-19 infection exacerbates the risk of developing heart failure, particularly in patients with pre-existing conditions.

Approach:

  • This review synthesizes current research on pathogen-driven heart failure in COVID-19 patients.
  • It examines the impact of common cardiovascular and anti-infective drugs on these patients.
  • Potential theoretical frameworks for clinical treatment are discussed.

Key Points:

  • Heart failure in COVID-19 results from intricate interactions involving pre-existing conditions, cardiac injury, renin-angiotensin system activation, and systemic inflammation.
  • Understanding these complex interactions is crucial for managing cardiovascular complications.
  • Drug interactions and therapeutic strategies require careful consideration.

Conclusions:

  • Further research is needed to establish a robust theoretical basis for treating COVID-19-associated heart failure.
  • Optimizing treatment involves addressing both the viral infection and its cardiovascular sequelae.
  • Multidisciplinary approaches are essential for improving patient outcomes.

Keywords:
Angiotensin (Ang)-converting enzyme 2COVID-19cardiac failurecardiovascular diseaseclinical outcomestherapeutic strategies

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