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Intragastric pH measurement using a novel disposable sensor.

M J Heath1, J D Owen, S W Sanders

  • 1Zinetics Medical Technology Inc., Salt Lake City, Utah.

Intensive Care Medicine
|January 1, 1988
PubMed
Summary
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A novel disposable pH sensor integrated into nasogastric tubes accurately measures gastric acidity. This innovative device shows high correlation with standard electrodes, offering a reliable tool for clinical monitoring.

Area of Science:

  • Biomedical Engineering
  • Gastroenterology
  • Medical Device Technology

Background:

  • Accurate gastric pH monitoring is crucial for diagnosing and managing various gastrointestinal conditions.
  • Current methods for gastric pH measurement can be invasive or cumbersome.
  • There is a need for a simple, reliable, and disposable pH sensing solution for nasogastric tubes.

Purpose of the Study:

  • To evaluate the accuracy and reliability of a novel disposable pH sensor integrated into a nasogastric tube.
  • To compare the performance of the disposable sensor against a standard indwelling miniature glass membrane electrode.
  • To assess the sensor's utility in healthy human volunteers.

Main Methods:

  • A unique disposable pH sensor was molded into the distal end of a nasogastric tube.

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  • The sensor's performance was evaluated in twelve healthy human volunteers.
  • Correlation analysis was performed using Spearman's rank correlation coefficient (rs) comparing the disposable sensor with an indwelling miniature glass membrane electrode and aspirated stomach fluid.
  • Sensor accuracy was verified using laboratory pH buffers before and after the clinical study.

    • Main Results:

    • The disposable pH sensor demonstrated a high correlation (rs = 0.90) with an indwelling miniature glass membrane electrode.
    • Correlation with aspirated stomach fluid was lower (rs = 0.68).
    • The sensor required no calibration and maintained accuracy of +/- 0.1 pH in laboratory buffers.
    • Both bare and shielded disposable sensors showed close agreement with a shielded miniature glass electrode.

    Conclusions:

    • The disposable pH sensor integrated into a nasogastric tube is a highly accurate and reliable device for measuring gastric pH.
    • The sensor shows excellent agreement with established methods, suggesting its potential for clinical application.
    • This technology offers a convenient and calibration-free solution for gastric acidity monitoring via nasogastric tubes.