Related Experiment Video
Updated: Nov 10, 2025
07:54
Drug-Induced Sleep Endoscopy DISE with Target Controlled Infusion TCI and Bispectral Analysis in Obstructive Sleep Apnea
Published on: December 6, 2016
20.2K
Does Sleep Position Influence Sleep-Disordered Breathing in Infants With Cleft Palate: A Feasibility Study?
Clare S Murray1,2, Tanya Walsh3, Trisha Bannister4
1Division of Infection, Immunity and Respiratory Medicine, School of Biological Sciences, University of Manchester, Manchester, UK.
Summary
Investigating sleep position in infants with cleft palate (CP) is crucial for managing sleep-disordered breathing (SDB). This study found oxygen saturation monitoring feasible, suggesting different sleep positions may impact SDB, warranting further research.
Area of Science:
- Pediatric Pulmonology
- Sleep Medicine
- Craniofacial Anomalies
Background:
- Cleft palate (CP) can lead to breathing difficulties and sleep-disordered breathing (SDB) in infants.
- The optimal sleep position for infants with CP to mitigate SDB is currently unknown.
- Sleep position is a modifiable factor that may influence SDB severity.
Purpose of the Study:
- To design a pragmatic study investigating the effect of two routinely advised sleep positions (supine vs. side-lying) in infants with CP on oxygen saturations.
- To assess the feasibility and acceptability of home monitoring of oxygen saturation (SpO2) and end-tidal carbon dioxide (ETCO2) in this population.
- To gather preliminary data to inform a future randomized controlled trial.
Main Methods:
- A multicentered observational cohort study was conducted across four UK cleft centers.
- Infants with isolated CP were recruited and monitored at 1 and 3 months of age.
- Home monitoring included SpO2 and ETCO2, supplemented by qualitative parent interviews.
Main Results:
- Oxygen saturation (SpO2) monitoring was feasible, with sufficient recordings obtained in 24 infants (13 side-lying) at 1 month and 19 infants (10 side-lying) at 3 months.
- End-tidal carbon dioxide (ETCO2) monitoring proved challenging, with limited successful recordings and reported unacceptability by parents.
- Parents emphasized the importance of sleep position management for infants with CP.
Conclusions:
- Domiciliary SpO2 monitoring is feasible in infants with CP within a research setting.
- Preliminary findings suggest potential differences in SpO2 based on sleep position, meriting further investigation.
- A randomized study comparing side-lying and supine sleep positions is recommended to better understand SDB in infants with CP.
Related Concept Videos
01:21Sleep Apnea
283
Sleep apnea is a condition where breathing stops intermittently during sleep, often leading to significant health issues. Each episode can last from 10 to 20 seconds or more and is frequently accompanied by a brief arousal from sleep. This disturbance, largely unnoticed by the individual, can lead to severe daytime fatigue. Commonly, individuals seek help after being informed by their partners about loud snoring and noticeable breathing pauses during sleep.
The condition is more prevalent among...
The condition is more prevalent among...
283
01:22Cardiopulmonary Resuscitation II: ACLS Airway Management
265
Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned...
265
01:11Anatomical Positions
17.5K
In anatomy, several standard anatomical positions are used as references for describing the position and orientation of different body parts. These positions help provide a common frame of reference when discussing anatomical structures. The anatomical position is the standard reference point for describing the body's position and orientation. In this position:
The body is upright, facing forward, and standing erect.
The feet are parallel and flat on the floor.
The arms are hanging by the...
The body is upright, facing forward, and standing erect.
The feet are parallel and flat on the floor.
The arms are hanging by the...
17.5K