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Updated: Nov 10, 2025
08:56
Simultaneous Imaging and Flow-Cytometry-based Detection of Multiple Fluorescent Senescence Markers in Therapy-Induced Senescent Cancer Cells
Published on: July 12, 2022
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Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy
Pataje G Prasanna1, Deborah E Citrin1, Jeffrey Hildesheim1
1National Cancer Institute, NIH, Bethesda, MD, USA.
Journal of the National Cancer Institute
|April 1, 2021
Summary
Cellular senescence, a key tumor suppressor, can paradoxically aid cancer relapse and therapy resistance. Targeting senescent cells (SnCs) offers a promising strategy for novel cancer treatments.
Area of Science:
- Oncology
- Cell Biology
- Cancer Therapeutics
Background:
- Cellular senescence is a crucial tumor suppressive mechanism.
- Cancer therapies can induce senescent cells (SnCs), which may promote tumor progression and side effects.
- Senescence plays a dual role in cancer, acting as both a suppressor and a potential promoter.
Purpose of the Study:
- To summarize discussions from the NCI Workshop on Radiation, Senescence, and Cancer.
- To review the current status of senescence research, senotherapeutics, and biomarkers.
- To explore novel therapeutic strategies like the "one-two punch" approach for cancer treatment.
Main Methods:
- Review of preclinical studies on therapy-induced senescence.
- Discussion of findings from the National Cancer Institute Workshop.
- Synthesis of current knowledge on senescence heterogeneity and senotherapeutics.
Main Results:
- Therapy-induced senescent cells accumulate in tumors and normal tissues.
- Senescent cells in tumors can paradoxically promote relapse, metastasis, and resistance.
- Senescent cells in normal tissues contribute to treatment-related side effects.
Conclusions:
- Cellular senescence presents a complex target in cancer therapy.
- Senotherapeutics and biomarkers are advancing, alongside concepts like "one-two punch" therapy.
- Addressing knowledge gaps in senescence research is vital for improving cancer patient outcomes.
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