Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polymeric IgA and IgA rheumatoid factor decrease the capacity of serum to solubilize circulating immune complexes in

P F Schena1, A Pastore, R A Sinico

  • 1Chair of Medical Therapy, University of Bari, Italy.

Journal of Immunology (Baltimore, Md. : 1950)
|July 1, 1988
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First Measurement of Time-Dependent CP Violation in the Flavor-Changing Neutral-Current Decay B^{0}→K_{S}^{0}μ^{+}μ^{-}.

Physical review letters·2026
Same author

Measurement of the Top-Quark Production Cross Section and Charge Asymmetry at LHCb.

Physical review letters·2026
Same author

Searches for B^{0}→K^{+}π^{-}τ^{+}τ^{-} and B_{s}^{0}→K^{+}K^{-}τ^{+}τ^{-} Decays.

Physical review letters·2026
Same author

First Evidence of the B_{s}^{0}→K^{-}π^{+}γ Decay.

Physical review letters·2026
Same author

Precision Measurement of CP Violation and Branching Fractions in B^{±}→K_{S}^{0}h^{±} (h=π, K) Decays and Search for the Rare Decay B_{c}^{±}→K_{S}^{0}K^{±}.

Physical review letters·2026
Same author

First Observation of the B[over ¯]_{s}^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay and Evidence for the B[over ¯]^{0}→Λ_{c}^{+}Λ[over ¯]_{c}^{-} Decay.

Physical review letters·2026

Patients with IgA nephropathy (IgAN) have impaired immune complex (IC) solubilization due to high levels of polymeric IgA (pIgA) and IgA rheumatoid factor (RF). These factors inhibit the body's ability to clear harmful ICs, contributing to disease progression.

Area of Science:

  • Nephrology
  • Immunology
  • Complement System

Background:

  • Primary IgA nephropathy (IgAN) is marked by immune complex (IC) deposition.
  • Patients exhibit elevated polymeric IgA (pIgA) and IgA rheumatoid factor (RF).
  • Serum's capacity to solubilize IC is impaired despite normal complement hemolytic activity.

Purpose of the Study:

  • To investigate if pIgA and IgA RF from IgAN patients inhibit normal serum's IC solubilization capacity.
  • To analyze the role of pIgA and IgA RF in the impaired complement-mediated solubilization observed in IgAN.

Main Methods:

  • Assessed the ability of IgAN patient serum to solubilize preformed immune precipitates (BSA-anti-BSA) in vitro.
  • Measured serum levels of pIgA and IgA RF in IgAN patients.

Related Experiment Videos

  • Correlated pIgA and IgA RF levels with the capacity of serum to solubilize IC.

    • Main Results:

    • IgAN patient serum showed significantly reduced capacity to solubilize immune precipitates in vitro (p < 0.001).
    • Significantly elevated mean levels of pIgA (p < 0.001) and IgA RF (p < 0.005) were found in IgAN patients.
    • Increasing pIgA and IgA RF levels inversely correlated with IC solubilization capacity (r = -0.36 and r = -0.57, respectively).

    Conclusions:

    • pIgA and IgA RF likely inhibit the complement-mediated solubilization of immune complexes in IgAN.
    • This impaired clearance may lead to the persistence of nephritogenic ICs in the circulation of IgAN patients.
    • Further research into the role of pIgA and IgA RF in IgAN pathogenesis is warranted.