Related Experiment Video
Updated: Nov 10, 2025
Imaging Local Ca2+ Signals in Cultured Mammalian Cells
Published on: March 3, 2015
Spindle cell tumour with thymus-like differentiation (SETTLE) on fine needle aspiration cytology: A case report
Oluyori K Adegun1, Ian Proctor1, Mary Falzon1
1Department of Cellular Pathology, University College London Hospitals NHS Foundation Trust, London, UK.
Abstract:
A 7-year-old girl presented with a painless neck swelling localised near the left lobe of the thyroid gland, which was initially investigated by fine needle aspiration cytology. This raised a differential diagnosis of medullary thyroid carcinoma and small round blue cell tumour. Only after several additional clinical investigations and a total thyroidectomy was a definitive diagnosis of spindle cell tumour with thymus-like differentiation (SETTLE) reached. This case report highlights how contemporaneous clinical and investigation findings made arriving at a definitive diagnosis challenging, contributed to diagnostic delay, and ultimately influenced choice of treatment.
