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Sequence of two mRNAs encoding active rat tryptophan hydroxylase
M C Darmon1, B Guibert, V Leviel
1Laboratoire de Neurobiologie Cellulaire, CNRS, Gif-sur-Yvette; France.
Journal of Neurochemistry
|July 1, 1988
Abstract:
Two full-length cDNA clones that encode functional rat tryptophan hydroxylase (EC 1.14.16.4), the key enzyme in serotonin synthesis, have been isolated from a rat pineal gland library. These two clones correspond to the 1.8- and 4-kilobase mRNA species, respectively. They contain the same coding sequence corresponding to a 51,010-dalton protein and differ in the length of their 3' untranslated regions.