[Sensitization pattern of cat and dog dander allergen in 16 426 patients with allergic diseases]

Objective:To explore the sensitization feature of cat and dog dander and time trend in northern region. Methods:During year 2017 to year 2019, subjects with self-reported allergic diseases received skin prick test for cat and dog dander allergen. Skin index（SI） ≥2+ was considered as positive SPT. SI2+ was defined as mild sensitization, SI3+ was defined as moderate sensitization while SI4+ was defined as severe sensitization. The age and gender difference of sensitization rate between cat and dog dander allergen was analyzed. Meanwhile, the trend of cat and dog dander sensitization rate was analyzed. Results:Overall, 16 426 subjects were enrolled in this study. ① The sensitization rate of cat dander was significantly higher than dog dander（11.8% vs 6.0%, P<0.001）. Severe sensitization rate of cat dander was significantly higher than dog dander（5.9% vs 1.7%, P<0.001） while there was no significant difference of mild sensitization rate. ②Sensitization age of cat dander was younger than dog dander（P<0.001）. Sensitization rate of cat and dog dander was higher in subjects ≤18y compared with those >18y（20.2% vs 10.9%, P<0.001; 8.1% vs 5.7%, P<0, 001）. The highest sensitization rate was presented in 13-18y age group（27.3% vs 9.9%, P<0.001）, following by 7-12y age group（26.0% vs 9.2%, P<0.001）. Sensitization rate of cat dander was higher in male than in female（13.7% vs 10.7%, P<0.001） while no gender difference was observed in dog dander sensitization（6.2% vs 5.8%, P=0.411）. ③595 subjects（3.6%） were both sensitized to cat and dog dander while 1733 subjects（10.6%） were sensitized either to cat or dog dander. Single sensitization rate of cat dander was higher than single sensitization rate of dog dander（8.2% vs 2.3%, P<0.001）. There was a positive correlation between the cat and dog dander sensitization rate（r=0.386, P<0.001）. ④During 2017-2019, the sensitization rate of cat dander increased but without significantly statistic difference while dog dander sensitization rate was descending from 7.4% to 4.6% significantly（χ²=38.298, P<0.001）. Conclusion:Cat dander sensitization rate was higher than dog dander with a peak age in adolescence. A trend of rising for cat dander allergy and descending for dog dander allergy was observed during the past three years.