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Apigenin role as cell-signaling pathways modulator: implications in cancer prevention and treatment

Zeeshan Javed1, Haleema Sadia2, Muhammad Javed Iqbal3

  • 1Office for Research Innovation and Commercialization, Lahore Garrison University, Sector-C, Phase VI, DHA, Lahore, 54792, Pakistan.

Cancer Cell International
|April 2, 2021
PubMed

Insights

Apigenin, a natural flavonoid found in fruits and vegetables, shows promise as an anticancer agent by regulating oncogenic pathways and interacting with microRNAs. Its nano-formulations offer potential for targeted cancer therapy with fewer side effects.

Area of Science:

  • Natural product chemistry
  • Molecular oncology
  • Pharmacology

Background:

  • Cancer arises from complex intrinsic and extrinsic pathways.
  • Natural product-derived compounds are explored for cancer therapeutics with minimal adverse effects.
  • Apigenin, a flavonoid abundant in fruits and vegetables, possesses documented pharmacological properties.

Purpose of the Study:

  • To review apigenin's role in regulating oncogenic pathways across various cancers.
  • To explore apigenin's interaction with microRNAs in modulating cellular processes.
  • To highlight nano-formulations of apigenin for targeted cancer therapy.

Main Methods:

  • Literature review of preclinical and clinical studies on apigenin's anticancer effects.
  • Analysis of molecular mechanisms, including apoptotic regulation, cell signaling, and protein networks.
  • Investigation of apigenin's interaction with microRNAs and its impact on cellular processes.
  • Examination of nano-formulation strategies for apigenin delivery.

Main Results:

  • Apigenin demonstrates anticancer activities by modulating key oncogenic pathways.
  • Apigenin interacts with microRNAs to regulate critical cellular functions relevant to cancer.
  • Nano-formulations enhance apigenin's targeted delivery and therapeutic potential.

Conclusions:

  • Apigenin is a promising natural compound for cancer therapy.
  • Understanding apigenin's molecular interactions, including with microRNAs, is crucial for its therapeutic application.
  • Apigenin nano-formulations represent a significant advancement in targeted cancer treatment strategies.
Keywords:
ApigeninCell signalingMicroRNAsNano-formulationsTherapeutic benefits

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