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Related Experiment Videos

Antibiotic release from an experimental biodegradable bone cement.

T N Gerhart1, R D Roux, G Horowitz

  • 1Department of Orthopaedic Surgery, Charles A. Dana Research Institute, Boston, Massachusetts.

Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society
|January 1, 1988
PubMed
Summary
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A new biodegradable bone cement (PPF-MMA) effectively delivered antibiotics locally, outperforming traditional PMMA. This offers a promising, biodegradable option for treating bone infections like chronic osteomyelitis.

Area of Science:

  • Biomaterials Science
  • Orthopedic Surgery
  • Infectious Disease Research

Background:

  • Polymethylmethacrylate (PMMA) is widely used but non-biodegradable.
  • Chronic osteomyelitis requires sustained local antibiotic delivery.
  • Biodegradable carriers could improve antibiotic elution and reduce complications.

Purpose of the Study:

  • To compare a novel biodegradable poly(propylene fumarate)-methylmethacrylate (PPF-MMA) bone cement with PMMA as a local antibiotic carrier.
  • To evaluate the in vivo antibiotic release profile and efficacy of PPF-MMA.
  • To assess the impact of antibiotic admixture on PPF-MMA mechanical properties.

Main Methods:

  • Subcutaneous implantation of antibiotic-loaded PMMA and PPF-MMA in rats.
  • Quantification of gentamicin and vancomycin levels in wound fluid and serum over 14 days using immunoassays.

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  • Microbiological assessment via agar diffusion techniques.
  • Mechanical testing of antibiotic-loaded PPF-MMA.

    • Main Results:

    • PPF-MMA achieved significantly higher and more sustained wound antibiotic levels compared to PMMA.
    • Vancomycin levels in wound fluid were over 20 times higher with PPF-MMA versus PMMA.
    • Serum antibiotic concentrations remained below safe therapeutic levels for both cements.
    • Incorporating 3% antibiotic did not compromise PPF-MMA mechanical integrity.

    Conclusions:

    • Biodegradable PPF-MMA cement serves as an effective carrier for sustained local antibiotic delivery.
    • PPF-MMA demonstrates superior antibiotic elution compared to PMMA, with low systemic absorption.
    • Its biodegradability eliminates the need for removal surgery, making it ideal for chronic osteomyelitis treatment.