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Skin Necrosis Following Inadvertent Dermal Injection of Extended-release Buprenorphine
Ericka Crouse1, Justin Haught, Natasha Tobarran
1Department of Pharmacotherapy & Outcomes Science, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia (EC), Department of Dermatology, Virginia Commonwealth University Health System, Richmond, Virginia (JH, CN), Virginia Poison Center, Division of Clinical Toxicology, Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond, Virginia (NT, KC, BW), Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond, Virginia (NT, KC, BW).
Introduction:
Extended-release subcutaneous buprenorphine injection is a relatively new formulation and clinicians are still gaining experience with its use. There is sparse literature available on adverse events. We describe a case of skin necrosis associated with the injection site of extended-release buprenorphine.
Case Report:
A 35-year-old reported immediate swelling and eventual skin breakdown near his buprenorphine injection site. He was found to have ulceration down to the subcutis with no evidence of infection. The patient followed up with dermatology and underwent debridement of the site. The injection site healed with scar formation.
Discussion:
Although mild to moderate adverse events related to the injection site have been reported in Phase 3 studies of extended-release buprenorphine injection, this is a rare case of skin necrosis requiring surgical intervention and excision of the depot.
Conclusions:
This case highlights the potential complication of skin necrosis after inadvertent dermal of extended-release buprenorphine and reviews proper administration techniques.
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