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Updated: Nov 10, 2025

One-pot Microwave-assisted Conversion of Anomeric Nitrate-esters to Trichloroacetimidates
Published on: January 15, 2018
HCl•DMPU-Assisted One-pot and Metal-free Conversion of Aldehydes to Nitriles
Sagar R Mudshinge1, Chinmay S Potnis1, Bo Xu2
1Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, United States.
Abstract:
We report an efficient HCl•DMPU assisted one-pot conversion of aldehydes into nitriles. The use of HCl•DMPU as both an acidic source as well as a non-nucleophilic base constitutes an environmentally mild alternative for the preparation of nitriles. Our protocol proceeds smoothly without the use of toxic reagents and metal catalysts. Diverse functionalized aromatic, aliphatic and allylic aldehydes incorporating various functional groups were successfully converted to nitriles in excellent to quantitative yields. This protocol is characterized by a broad substrate scope, mild reaction conditions, and high scalability.
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