Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Quality Assurance01:19

Quality Assurance

574
Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
574
Quality Control01:05

Quality Control

760
Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
Quality control helps track data, visualize trends, and identify variations, making it easier to detect deviations that may affect the accuracy of an analysis. One way to do this is by generating a quality control chart, which...
760
Clinical Trials01:16

Clinical Trials

9.9K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
9.9K
Clinical Trials: Overview01:11

Clinical Trials: Overview

4.1K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
4.1K
Clinically Relevant Drug Product Specifications: Methods of Establishment01:29

Clinically Relevant Drug Product Specifications: Methods of Establishment

74
Product specifications define the acceptable quality of a pharmaceutical product by ensuring identity, purity, potency, and strength. These specifications serve as benchmarks during development, manufacturing, and post-approval quality control. Clinically relevant specifications are particularly important because they directly relate to a drug's safety and efficacy in clinical use.Dissolution studies are critical biopharmaceutic tools that link in vitro behavior to in vivo performance. They...
74
In Vitro Drug Release Testing: Overview, Development and Validation01:10

In Vitro Drug Release Testing: Overview, Development and Validation

86
In vitro dissolution and drug release tests assess how quickly and how much of a drug is released from its dosage form into an aqueous medium under standardized laboratory conditions. These tests are essential tools in pharmaceutical development and quality assurance, offering insight into the drug's performance before clinical use.During formulation development, dissolution testing identifies incomplete or inconsistent drug release issues. It also supports decisions on selecting the optimal...
86

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A symposium update on the key perspectives in systemic sclerosis and systemic lupus erythematosus.

Journal of translational autoimmunity·2026
Same author

Methodology and quality assurance practices in performing anti-extractable nuclear antigen (ENA) analysis: an EFLM report on an international survey.

Clinical chemistry and laboratory medicine·2026
Same author

International expert consensus recommendations on standardised nomenclature of SSA/Ro (TROVE2/Ro60 and TRIM21/Ro52) autoantibodies in autoimmune diseases.

Annals of the rheumatic diseases·2026
Same author

Autoantibody and biomarker detection in the follow-up of autoimmune diseases: state of the art and future perspectives.

Journal of translational autoimmunity·2026
Same author

Towards harmonization of autoantibody detection in relation to paraneoplastic neurological syndromes (PNS): a European Survey on laboratory practices.

Clinical chemistry and laboratory medicine·2025
Same author

T-cell immunity in the experimental autoimmune vasculitis rat model.

Journal of translational autoimmunity·2025

Related Experiment Video

Updated: Nov 10, 2025

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
09:30

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Published on: March 17, 2023

3.9K

ANCA Testing in Clinical Practice: From Implementation to Quality Control and Harmonization.

Jan Damoiseaux1

  • 1Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, Netherlands.

Frontiers in Immunology
|April 2, 2021
PubMed
Summary

Anti-neutrophil cytoplasmic antibody (ANCA) testing is crucial for diagnosing small vessel vasculitis. This review explores ANCA assay applications beyond initial diagnosis, including therapy monitoring and relapse prediction in ANCA-associated vasculitis.

Keywords:
harmonizationmyeloperoxidaseproteinase 3standardizationvasculitis

More Related Videos

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications
14:14

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

16.1K
Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

16.9K

Related Experiment Videos

Last Updated: Nov 10, 2025

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies
09:30

Author Spotlight: Microbial Control and Monitoring Strategies for Cleanroom Environments and Cellular Therapies

Published on: March 17, 2023

3.9K
Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications
14:14

Adaptation of Semiautomated Circulating Tumor Cell CTC Assays for Clinical and Preclinical Research Applications

Published on: February 28, 2014

16.1K
Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model
23:56

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

16.9K

Area of Science:

  • Immunology
  • Rheumatology
  • Clinical Chemistry

Background:

  • Anti-neutrophil cytoplasmic antibodies (ANCA) are vital biomarkers for diagnosing small vessel vasculitis.
  • Current immunoassays for ANCA are primarily optimized for diagnosing ANCA-associated vasculitis (AAV).
  • Implementation, quality control, and harmonization efforts for ANCA testing focus mainly on AAV diagnosis.

Purpose of the Study:

  • To review the broader applications of ANCA testing in clinical practice.
  • To discuss the implementation, quality control, and standardization/harmonization of ANCA assays.
  • To consider ANCA testing for monitoring therapy efficacy and predicting relapse in AAV patients.

Main Methods:

  • Literature review of ANCA testing methodologies and applications.
  • Analysis of current practices in ANCA assay implementation and quality control.
  • Discussion of standardization versus harmonization in the context of ANCA detection.

Main Results:

  • ANCA testing extends beyond initial AAV diagnosis to include monitoring and relapse prediction.
  • Challenges exist in implementing, controlling quality, and harmonizing ANCA assays for diverse clinical uses.
  • The review highlights the need for adaptable ANCA testing strategies.

Conclusions:

  • ANCA assays have multifaceted roles in managing AAV patients, including therapeutic monitoring and relapse prediction.
  • Optimizing ANCA testing requires addressing implementation, quality control, and harmonization for various clinical scenarios.
  • Standardization and harmonization are critical for reliable ANCA detection across different applications.