Aggressive lesion in osseous sarcoidosis

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R S Lesser1, S Dadparvar, A A Weiss

  • 1Department of Orthopedic Surgery, Hahnemann University School of Medicine, Philadelphia, PA.

The Journal of Rheumatology
|March 1, 1988
PubMed

Abstract:

We describe an unusual aggressive lytic bone lesion with "sunburst/hair-on-end" periosteal reaction in a patient with surgically proven osseous sarcoid and review the pertinent literature.

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...

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