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Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins
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Advances in Aptamer-Based Biomarker Discovery.

Jie Huang1, Xinxin Chen1, Xuekun Fu1

  • 1Department of Biology, Southern University of Science and Technology, Shenzhen, China.

Frontiers in Cell and Developmental Biology
|April 2, 2021
PubMed
Summary
This summary is machine-generated.

Aptamer-based technologies like CELL-SELEX and SOMAScan offer advanced methods for biomarker discovery. These tools accelerate the development of medical diagnostics and therapeutics by identifying novel biomarkers for various diseases.

Keywords:
CELL-SELEXSOMAScanaptamerbiomarker discoveryhuman diseases

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Medical Diagnostics

Background:

  • Biomarker discovery is crucial for developing medical diagnostics and therapeutics.
  • Current technologies for biomarker discovery are suboptimal, limiting clinical applications.
  • Aptamers, nucleic acid molecules with high target affinity and specificity, offer advantages over antibodies for biomarker discovery.

Purpose of the Study:

  • To introduce aptamer-based biomarker discovery technologies.
  • To summarize recent advancements in aptamer-based biomarker discovery.
  • To highlight emerging biomarkers identified using aptamer technologies in various diseases.

Main Methods:

  • Review of aptamer-based technologies, including CELL-SELEX and SOMAScan.
  • CELL-SELEX for identifying cell surface biomarkers.
  • SOMAScan for large-scale, unbiased multi-protein biomarker discovery in complex samples.

Main Results:

  • Aptamers offer advantages in design, synthesis, and modification compared to antibodies.
  • CELL-SELEX is effective for cell surface biomarker identification.
  • SOMAScan enables high-throughput analysis of thousands of proteins for biomarker discovery.

Conclusions:

  • Aptamer-based technologies are powerful tools for accelerating biomarker discovery.
  • These technologies facilitate the identification of novel biomarkers for improved medical diagnosis and therapeutics.
  • The review highlights emerging biomarkers and their potential impact on disease management.