Related Experiment Video

Updated: Nov 10, 2025

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
12:12

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice

Published on: February 14, 2017

16.4K

Echocardiographic Characteristics and Outcome in Patients With COVID-19 Infection and Underlying Cardiovascular

Yuman Li1,2,3, Lingyun Fang1,2,3, Shuangshuang Zhu1,2,3

  • 1Department of Ultrasound, Tongji Medical College, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.

Frontiers in Cardiovascular Medicine
|April 2, 2021
PubMed

Insights

Patients with COVID-19 and cardiovascular disease (CVD) show impaired right ventricular (RV) function, which predicts higher mortality. Echocardiography reveals RV dysfunction is common and linked to elevated troponin levels in these patients.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Cardiac manifestations in COVID-19 patients with pre-existing cardiovascular disease (CVD) require further clarification.
  • Understanding the prognostic implications of echocardiographic findings in this population is crucial.

Purpose of the Study:

  • To investigate the prognostic value of echocardiographic parameters in hospitalized COVID-19 patients with underlying CVD.
  • To assess the impact of CVD on cardiac structure and function in COVID-19 patients.

Main Methods:

  • Bedside echocardiography was used to evaluate left ventricular (LV) and right ventricular (RV) structure and function.
  • 157 hospitalized COVID-19 patients were analyzed, with 89 having pre-existing CVD.

Main Results:

  • COVID-19 patients with CVD exhibited higher mortality (22.5% vs. 4.4%) and more clinical events compared to those without CVD.
  • Impaired RV systolic function and LV diastolic dysfunction were more prevalent in CVD patients.
  • RV dysfunction was the most frequent finding (30.3%), followed by LV diastolic (9.0%) and systolic dysfunction (5.6%).
  • Impaired RV function was associated with elevated high-sensitivity troponin I (hs-TNI) and predicted higher mortality.

Conclusions:

  • COVID-19 patients with underlying CVD display impaired LV diastolic and RV function, but typically normal LV systolic function.
  • Echocardiographic assessment of RV function is a key predictor of mortality in COVID-19 patients with CVD.

Keywords:
COVID-19cardiac functioncardiac injurycardiovascular diseaseechocardiography

More Related Videos

Author Spotlight: Workflow for Integrating POCUS Data into EHR for Managing Heart Failure Patients03:47

Author Spotlight: Workflow for Integrating POCUS Data into EHR for Managing Heart Failure Patients

Published on: July 12, 2024

989
Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients08:45

Echocardiographic Assessment Using Subxiphoid-Only Examination for Hypotensive Patients

Published on: April 18, 2025

716

Related Concept Videos

Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
562
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
124
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
159
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
204
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
76
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
190