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Long-range PEG Stapling: Macrocyclization for Increased Protein Conformational Stability and Resistance to

Qiang Xiao1, Dallin S Ashton1, Zachary B Jones1

  • 1Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, United States.

RSC Chemical Biology
|April 2, 2021
PubMed
Summary

Protein stapling with PEG oligomers enhances conformational stability. This method improves protein folding and resistance to degradation, applicable to various protein types like WW and SH3 domains.

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