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Updated: Nov 10, 2025

Preparation of Hydroxy-PAAm Hydrogels for Decoupling the Effects of Mechanotransduction Cues
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Aptamer-Modified Hydrogels.

Johanna-Gabriela Walter1

  • 1Institut für Technische Chemie, Leibniz Universität Hannover, Hannover, Germany. walter@iftc.uni-hannover.de.

Advances in Biochemical Engineering/Biotechnology
|April 2, 2021
PubMed
Summary

Combining hydrogels with aptamers creates smart materials that respond to biological signals. This innovation enables advanced biosensing, tissue engineering, and drug delivery applications.

Area of Science:

  • Biomaterials Science
  • Biotechnology
  • Nanotechnology

Background:

  • Hydrogels are widely recognized for their biocompatibility and stimulus-responsive properties.
  • Integrating aptamers introduces biological recognition capabilities to hydrogels.
  • This combination unlocks potential for sophisticated biosensing and biomedical applications.

Purpose of the Study:

  • To introduce aptamers and their role in imparting biological responsiveness to hydrogels.
  • To explain aptamer-based mechanisms driving hydrogel responsiveness.
  • To provide examples of these mechanisms in various applications.

Main Methods:

  • Review and explanation of aptamer-based mechanisms for hydrogel responsiveness.
  • Discussion of aptamer-hydrogel conjugation strategies.
Keywords:
AptamersBiomedicineBiosensingHydrogelsTarget-responsive hydrogels

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  • Case studies illustrating applications in sensing, tissue engineering, and drug delivery.

    • Main Results:

    • Aptamers enable hydrogels to recognize and respond to specific biological targets.
    • Aptamer-hydrogel systems demonstrate tunable and programmable responses.
    • Applications range from simple sensors to complex drug delivery and tissue engineering scaffolds.

    Conclusions:

    • The synergy between aptamers and hydrogels facilitates the development of smart, target-responsive materials.
    • Rational design using DNA techniques allows for precise control over hydrogel behavior.
    • This approach significantly advances the fields of biosensing and regenerative medicine.