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Modeled vascular microenvironments: immune-endothelial cell interactions in vitro.

Justin Silberman1, Aakanksha Jha2, Holly Ryan2

  • 1Materials Science and Engineering, University of Florida, FL, Gainesville, USA.

Drug Delivery and Translational Research
|April 2, 2021
PubMed
Summary

In vitro models enhance understanding of cell behavior in diseases like cancer. These studies focus on immune cell and endothelial cell interactions within the vascular microenvironment.

Keywords:
AngiogenesisCD4 T cellDisease modelEndothelial cellIn vitro modelsMacrophageMicrofluidicNeutrophil

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Area of Science:

  • Cell Biology
  • Immunology
  • Vascular Biology

Background:

  • In vitro techniques offer advanced observation of cellular processes and drug screening.
  • Recapitulating the vascular microenvironment is crucial for studying cardiovascular diseases and cancer.
  • Endothelial cells interact with immune cells, influencing disease progression.

Purpose of the Study:

  • To review in vitro methods for modeling immune cell-endothelial cell interactions.
  • To present recent findings on these interactions in disease contexts.
  • To highlight the role of the vascular microenvironment.

Main Methods:

  • Utilizing in vitro systems to mimic the vascular microenvironment.
  • Investigating interactions between endothelial cells and various immune cells (monocytes, macrophages, neutrophils, T cells).
  • Employing techniques such as flow, static culture, and indirect co-culture models.

Main Results:

  • In vitro studies reveal how immune cells modulate endothelial cell behavior.
  • Observed alterations in endothelial cell behavior are linked to cardiovascular diseases and tumor metastasis.
  • Cell-cell interactions and soluble signaling mediate these effects.

Conclusions:

  • In vitro models are valuable tools for dissecting complex immune cell-endothelial cell dynamics.
  • Understanding these interactions is key to developing new therapeutic strategies for vascular diseases and cancer.
  • Further research in this area will advance drug discovery and disease modeling.