Varicella Zoster Viral Retinitis following Chimeric Antigenic Response T-cell Therapy for B-cell Lymphoma
Waleed K Alsarhani1,2, Ahmed M Abu El-Asrar2,3
1Department of Ophthalmology, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
Purpose:
To describe the first case of varicella zoster virus (VZV) retinitis following chimeric antigenic response (CAR) T-cell therapy.
Methods:
Case review.
Results:
A 53-year-old male was treated with CAR T-cell therapy for refractory diffuse large B-cell lymphoma. Nine months after CAR T-cell therapy, he developed VZV skin infection and retinitis. The retinitis responded to systemic acyclovir therapy and intravitreal ganciclovir.
Conclusion:
VZV retinitis can occur following CAR T-cell immunotherapy.
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