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In-vitro Mutagenesis

In-vitro Mutagenesis

To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.

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Related Experiment Video

Updated: Nov 10, 2025

Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein

Removal of an Internal Translational Start Site from mRNA While Retaining Expression of the Full-Length Protein

Published on: March 16, 2022

Generating a CRISPR knockout mouse through a strong premature termination codon: a cautionary tale

Qing Rex Lyu^1,2,3, Peng Yao¹, Joseph M Miano^1,2

¹Aab Cardiovascular Research Institute, University of Rochester School of Medicine & Dentistry, Rochester, NY 14642, USA.

Journal of Biomedical Research

|April 2, 2021

Summary

No abstract available in PubMed .

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Last Updated: Nov 10, 2025

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