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Correction: Accorsi Buttini et al. Development of a Simplified Geriatric Score-4 (SGS-4) to Predict Outcomes After Allogeneic Hematopoietic Stem Cell Transplantation in Patients Aged over 50. <i>Cancers</i> 2025, <i>17</i>, 3278.

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Updated: Nov 10, 2025

Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
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Why data on frailty and SARS-CoV-2 infection are basic to progress.

A Zucchelli1, E Bologna2, A Marengoni3

  • 1Department of Information Engineering, Università degli Studi di Brescia, vle Branze 38, 25123, Brescia, Italy. a.zucchelli001@unibs.it.

Aging Clinical and Experimental Research
|April 2, 2021
PubMed
Summary
This summary is machine-generated.

Older adults with frailty may be more susceptible to SARS-CoV-2 infection. This case series found frailer individuals had higher antibody positivity after potential exposure to the virus.

Keywords:
COVID-19FrailtyOlder personsSARS-CoV-2

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Area of Science:

  • Gerontology
  • Infectious Diseases
  • Epidemiology

Background:

  • Frailty is a known predictor of mortality in older adults with COVID-19.
  • Mechanisms linking frailty to COVID-19 severity include immunosenescence and inflammation.
  • The susceptibility of frail individuals to SARS-CoV-2 infection is not well understood.

Purpose of the Study:

  • To investigate whether frailty is associated with increased susceptibility to SARS-CoV-2 infection.
  • To examine SARS-CoV-2 antibody positivity in a cohort of older adults with potential exposure.

Main Methods:

  • Case series of 40 older adults with potential SARS-CoV-2 exposure in February 2020.
  • Serological testing for SARS-CoV-2 antibodies offered between May and July.
  • Comparison of clinical characteristics, including frailty, between seropositive and seronegative individuals.

Main Results:

  • Twenty-seven individuals were tested for SARS-CoV-2 antibodies; 13 were positive.
  • No active infection was detected at the time of testing.
  • Individuals with positive serological tests exhibited higher Clinical Frailty Scale scores, indicating greater frailty.

Conclusions:

  • Frail older adults may have a higher susceptibility to SARS-CoV-2 infection.
  • Frailty, assessed by the Clinical Frailty Scale, is associated with SARS-CoV-2 antibody positivity.
  • Further research is needed to elucidate the mechanisms underlying this association.