Bridging the gap between single receptor type activity and whole-brain dynamics.

Area of Science:

• Neuroscience
• Computational Neuroscience
• Systems Neuroscience

Background:

• Understanding how individual neuronal receptor types influence large-scale brain network dynamics is crucial for brain function theories.
• The distribution and density of modulatory receptors across the brain's connectivity matrix are key factors.

Purpose of the Study:

• To investigate the effect of activating a single modulatory neuronal receptor type on whole-brain network dynamics.
• To introduce and validate the concept of the cortical 'receptome'.

Main Methods:

• In silico whole-brain modeling to simulate network dynamics.
• Optogenetic tools for specific in vivo activation of single serotonin (5-HT) receptor types.
• In vivo measurement of cortical processing changes.

Main Results:

• Demonstrated a bidirectional coupling between modulatory neurotransmission and neuronal connectivity.
• Showcased the impact of single serotonergic (5-HT) receptor types on cortical dynamics.
• Confirmed specific effects of single 5-HT receptor activation on cortical processing.

Conclusions:

• Structural neuronal connectivity, modulated by single neurotransmitter systems, enables diverse brain states essential for flexible behavior.
• Irregular receptor expression may predispose individuals to neuropsychiatric disorders like addiction, depression, and anxiety.
• Therapeutic interventions targeting specific receptors could potentially restore natural brain state transitions.