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Imaging Biological Samples with Optical Microscopy

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Optical microscopy uses optic principles to provide detailed images of samples. Antonie van Leeuwenhoek designed the first compound optical microscope in the 17th century to visualize blood cells, bacteria, and yeast cells. In 1830, Joseph Jackson Lister created an essentially modern light microscope. The 20th century saw the development of microscopes with enhanced magnification and resolution.
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Three-dimensional Optical-resolution Photoacoustic Microscopy

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LightSpeed: A Compact, High-Speed Optical-Link-Based 3D Optoacoustic Imager.

Cagla Ozsoy, Andrea Cossettini, Ali Ozbek

IEEE Transactions on Medical Imaging

|April 2, 2021

Summary

Introducing LightSpeed, a low-cost, handheld optoacoustic imager. This system achieves high-performance 3D human angiography at ultrafast speeds, making advanced imaging more accessible.

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Area of Science:

Biomedical imaging
Optoacoustic imaging
Medical technology

Background:

Optoacoustic imaging adoption is limited by scanner cost and complexity.
Need for affordable, user-friendly, high-performance imaging devices.

Purpose of the Study:

To introduce LightSpeed, a novel low-cost, real-time volumetric handheld optoacoustic imager.
To demonstrate its capability for ultrafast 3D human angiography.

Main Methods:

Development of a compact, software-defined ultrasound acquisition platform.
Integration with a pulsed laser diode and high-bandwidth optical link (2x 100G Ethernet).
Simultaneous acquisition from up to 192 ultrasound channels.

Main Results:

Demonstrated ultrafast (500Hz) 3D human angiography with a handheld probe.
Achieved image quality comparable to conventional systems.
Enabled high-speed imaging with a rapidly moving probe.

Conclusions:

LightSpeed offers a compact, affordable, and high-performance solution for optoacoustic imaging.
Paves the way for a new generation of accessible optoacoustic scanners.
Facilitates wider adoption in biology and medicine.