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Author Spotlight: Developing Immunocompetent Organ-on-Chip Models for Infectious Disease Research
Published on: May 24, 2024
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Organ-on-chip to investigate host-pathogens interactions.
Thomas Feaugas1, Nathalie Sauvonnet1
1Group Intracellular Trafficking and Tissue Homeostasis, Institut Pasteur, Paris, France.
Cellular Microbiology
|April 2, 2021
Summary
Organ-on-chip technology offers a new era for studying infectious diseases by recreating organ physiology. This method is crucial for understanding host-pathogen interactions at the tissue level.
Area of Science:
- Biomedical Engineering
- Infectious Diseases
- Tissue Engineering
Background:
- Infectious diseases research is advancing towards understanding host-pathogen interactions at the tissue scale.
- New methodologies are emerging to study these complex biological processes.
Purpose of the Study:
- To review the application of organ-on-chip technology in studying host-pathogen interactions.
- To highlight how organ-on-chip models recapitulate tissue architecture, mechanical stimulation, and interfaces.
Main Methods:
- Organ-on-chip technology combines biomaterial technology, microfluidics, and tissue engineering.
- These platforms recreate the physiological microenvironment of organs.
Main Results:
- Organ-on-chip models successfully replicate key aspects of tissue architecture and mechanical properties.
- The recapitulated microenvironment is critical for studying host-pathogen interactions.
Conclusions:
- Organ-on-chip technology represents a promising approach for in-depth study of infectious diseases.
- This technology provides a valuable platform for investigating host-pathogen interactions at the tissue scale.
