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Updated: Nov 10, 2025

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

Alginate enriched with phytic acid for hydrogels preparation.

Loredana Elena Nita¹, Aurica P Chiriac¹, Alina Ghilan¹

¹"Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley 41-A, RO-700487, Iasi, Romania.

International Journal of Biological Macromolecules

|April 2, 2021

Summary

Sodium alginate hydrogels crosslinked with phytic acid exhibit tunable properties for tissue regeneration. These superabsorbent, porous biomaterials show potential for various bio-applications.

Keywords:

Alginate Bio-crosslinker Hydrogel

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Last Updated: Nov 10, 2025

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Area of Science:

Biomaterials Science
Polymer Chemistry
Tissue Engineering

Background:

Alginate hydrogels are versatile biomaterials due to their similarity to the extracellular matrix.
This similarity makes them promising for cell and tissue regeneration applications.

Purpose of the Study:

To prepare and characterize superabsorbent, high-porous alginate hydrogels using phytic acid as a natural crosslinker.
To investigate the influence of alginate-to-phytic acid ratios on the hydrogels' physicochemical properties.

Main Methods:

Preparation of sodium alginate/phytic acid hydrogels with varying ratios.
Characterization using Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), X-ray diffraction (XRD), swelling tests, and simultaneous thermogravimetric analysis/FT-IR/mass spectrometry (TGA/FT-IR/MS).

Main Results:

Successful preparation of superabsorbent, high-porous alginate-phytic acid hydrogels.
Demonstrated differences in physicochemical properties (e.g., swelling, thermal stability) based on the alginate and phytic acid composition.
FT-IR, SEM, XRD, and thermal analysis confirmed the successful crosslinking and structural characteristics.

Conclusions:

Alginate-phytic acid hydrogels possess tunable properties influenced by their composition.
These hydrogels offer versatility for various bio-applications, particularly in cell and tissue regeneration.
The use of phytic acid as a natural crosslinker provides a promising route for developing advanced biomaterials.