3D printed sample tubes for solid-state NMR experiments.

Area of Science:

• Spectroscopy and Magnetic Resonance Imaging (MRI)

Background:

• Traditional Nuclear Magnetic Resonance (NMR) probe construction faces limitations in optimizing component integration and sample volume.
• Advancements in 3D printing offer new possibilities for designing and fabricating custom NMR probe components.

Purpose of the Study:

• To demonstrate the use of 3D printing for creating integrated radiofrequency (RF) coil formers and sample chambers in NMR probes.
• To enhance sample volume, filling factor, and experimental efficiency in NMR spectroscopy and imaging.

Main Methods:

• Utilizing computer-aided design (CAD) and precise 3D printing to fabricate integrated probe components.
• Designing probes that combine the sample chamber and the RF coil's permanent former within a fixed outer diameter.

Main Results:

• Successfully integrated the RF coil former with the sample chamber using 3D printing.
• Achieved increased sample volume and improved filling factor within a standard outer diameter.
• Reduced spatial inefficiencies in dual-coil arrangements, enhancing efficiency for multiple-resonance experiments.

Conclusions:

• 3D printing provides a powerful tool for reimagining NMR probe design and construction.
• This approach facilitates the creation of optimized interfaces between resonators and various sample types (liquid, solid, heterogeneous).
• The demonstrated methods open avenues for advanced NMR studies of biomolecules, polymers, surfaces, and in vivo imaging.