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Hydrogen Sulfide-Clues from Evolution and Implication for Neonatal Respiratory Diseases
Abhrajit Ganguly1, Gaston Ofman1, Peter F Vitiello1
1Center for Pregnancy and Newborn Research, Department of Pediatrics, Section of Neonatal-Perinatal Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA.
Children (Basel, Switzerland)
|April 3, 2021
Summary
Hydrogen sulfide (H2S) is a novel gasotransmitter with potential therapeutic benefits for neonatal respiratory diseases. Its role in lung development suggests promise for treating conditions like bronchopulmonary dysplasia (BPD).
Area of Science:
- Neonatal medicine
- Respiratory physiology
- Redox biology
Background:
- Reactive oxygen species (ROS) are implicated in neonatal respiratory diseases like bronchopulmonary dysplasia (BPD).
- Nitric oxide (NO) and carbon monoxide (CO) are known gaseous signaling molecules in lung development.
- Previous gaseous signaling therapies have shown limited success in human neonatal clinical trials.
Purpose of the Study:
- To explore the role of hydrogen sulfide (H2S) as a signaling pathway in neonatal lung development.
- To investigate the potential of H2S in treating oxidative neonatal respiratory diseases.
- To review evolutionary clues and future opportunities for H2S in neonatal chronic lung disease.
Main Methods:
- Review of existing literature on redox signaling, gaseous molecules, and lung development.
- Analysis of evolutionary data regarding early life dependence on H2S.
- Exploration of recent studies on H2S synthesizing enzymes in lung development.
Main Results:
- H2S has emerged as a significant gasotransmitter involved in cellular signaling.
- Early life-forms utilized H2S, suggesting its fundamental biological role.
- H2S and its synthesizing enzymes play a role in lung development within hypoxic environments.
Conclusions:
- The H2S signaling pathway presents a promising avenue for addressing neonatal oxidative respiratory diseases.
- Further research into H2S is warranted for potential therapeutic applications in neonatal chronic lung disease.
- Understanding H2S's role, informed by evolution, could revolutionize neonatal respiratory care.
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