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Related Concept Videos

In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

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Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients,...
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Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
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Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...
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Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

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Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Related Experiment Video

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Evaluation of Biodegradable PVA-Based 3D Printed Carriers during Dissolution.

Bálint Basa1, Géza Jakab1, Nikolett Kállai-Szabó1

  • 1Department of Pharmaceutics, Semmelweis University, Hőgyes E. Street 7-9, 1092 Budapest, Hungary.

Materials (Basel, Switzerland)
|April 3, 2021
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Summary

Polyvinyl alcohol (PVA) carriers fabricated using 3D printing dissolve in simulated conditions, with dissolution rates varying by medium. This research explores PVA

Keywords:
3D printingcomputer aided design (CAD)dissolution studydynamic light scattering (DLS)erosion testfused deposition modelling (FDM)

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Area of Science:

  • Pharmaceutical Manufacturing
  • Materials Science

Background:

  • Additive manufacturing, particularly 3D printing, offers significant potential for personalized pharmaceutical production.
  • Polyvinyl alcohol (PVA) is a commonly used material in pharmaceutical applications.

Purpose of the Study:

  • To investigate the in vitro dissolution behavior of polyvinyl alcohol (PVA) when used as a pharmaceutical carrier.
  • To compare the performance of PVA carriers with polylactic acid (PLA) carriers.
  • To assess the drug release kinetics from PVA carriers.

Main Methods:

  • Carriers were designed using computer-aided design (CAD) and fabricated via 3D printing.
  • Polyvinyl alcohol (PVA) and polylactic acid (PLA) carriers were subjected to in vitro dissolution tests under simulated biorelevant conditions.
  • Carrier behavior was monitored using gravimetry and dynamic light scattering (DLS).
  • Drug release was tracked using UV spectrophotometry.

Main Results:

  • PVA carriers dissolved in all tested dissolution media.
  • The particle size of dissolved PVA was consistently below 300 nm.
  • Dissolution rates varied across different dissolution media.
  • Drug release kinetics were successfully investigated, demonstrating potential for quality modification through computer-aided design.

Conclusions:

  • Polyvinyl alcohol (PVA) is a viable material for 3D printed pharmaceutical carriers, exhibiting dissolution characteristics that vary with the medium.
  • The study highlights the potential of computer-aided design and 3D printing to tailor drug delivery systems.
  • Further research can leverage these findings to optimize drug output and quality control in personalized medicine.