Hemorphins Targeting G Protein-Coupled Receptors
Mohammed Akli Ayoub1,2, Ranjit Vijayan1
1Department of Biology, College of Science, United Arab Emirates University, P.O. Box 15551 Al Ain, United Arab Emirates.
Pharmaceuticals (Basel, Switzerland)
|April 3, 2021
Summary
Hemorphins, derived from hemoglobin, interact with G protein-coupled receptors (GPCRs), influencing various physiological systems. This interaction highlights the hemorphin-GPCR axis as a potential therapeutic target.
Area of Science:
- Pharmacology
- Neuroscience
- Endocrinology
Background:
- Hemorphins are peptides from hemoglobin proteolysis with diverse physiological roles.
- They modulate proteins, including enzymes and receptors, impacting nervous and renin-angiotensin systems.
Purpose of the Study:
- To review the pharmacological and functional targeting of G protein-coupled receptors (GPCRs) by hemorphins.
- To explore the implications of hemorphin-GPCR interactions in physiology and pathophysiology.
Main Methods:
- Literature review focusing on hemorphin interactions with various GPCRs.
- Analysis of studies reporting orthosteric and allosteric modulation of GPCRs by hemorphins.
Main Results:
- Hemorphins target opioid receptors, implicated in analgesia.
- Other targeted GPCRs include those for angiotensin II, oxytocin, bombesin, bradykinin, and MAS-related G protein-coupled receptor X1.
- Both direct activation and allosteric modulation of GPCRs by hemorphins have been observed.
Conclusions:
- The hemorphin-GPCR axis is crucial for hemorphin effects in various physiological systems.
- Understanding this axis provides insight into the molecular basis of hemorphin action.
- The hemorphin-GPCR axis represents a viable therapeutic target for diverse conditions.
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