Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

2.4K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FDA-approved drug library screen identifies antidepressants, antimicrobials, anti-COPD, and anti-CVD agents as blockers of NLRP3 inflammasome and sepsis in a sex-dependent manner.

bioRxiv : the preprint server for biology·2026
Same author

Interplay Between Thrombospondin-1 and CD36 Modulates Platelet-RBC Interaction in Thrombosis and Abdominal Aneurysm Formation.

Circulation research·2025
Same author

Enigmatic functions of ATP8B1: cholestasis, inflammation, phosphoinositide flipping, and cellular homeostasis.

Cell cycle (Georgetown, Tex.)·2025
Same author

Association of Specific Antiphospholipid Antibodies to Platelet Count and Thrombocytopenia.

Thrombosis and haemostasis·2025
Same author

First- vs. Second-Generation Autologous Platelet Concentrates and Their Implications for Wound Healing: Differences in Proteome and Secretome.

Bioengineering (Basel, Switzerland)·2024
Same author

Cardiovascular and genetic determinants of platelet high responsiveness: results from the Gutenberg Health Study.

Blood advances·2024

Related Experiment Video

Updated: Nov 10, 2025

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.2K

Platelet Phenotyping and Function Testing in Thrombocytopenia.

Kerstin Jurk1, Yavar Shiravand2

  • 1Center for Thrombosis and Hemostasis (CTH), University Medical Center of the Johannes Gutenberg University Mainz, 55131 Mainz, Germany.

Journal of Clinical Medicine
|April 3, 2021
PubMed
Summary
This summary is machine-generated.

Platelet function defects in thrombocytopenia increase bleeding risk. This review examines practical diagnostic tests for platelet disorders, highlighting challenges in specialized labs.

Keywords:
bleedingflow cytometryplatelet countplatelet disordersplatelet function teststhrombocytopenia

More Related Videos

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.1K
Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
08:04

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

792

Related Experiment Videos

Last Updated: Nov 10, 2025

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.2K
A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

14.1K
Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
08:04

Analyzing Platelet Subpopulations by Multi-color Flow Cytometry

Published on: June 10, 2025

792

Area of Science:

  • Hematology
  • Clinical Pathology
  • Hemostasis and Thrombosis

Background:

  • Thrombocytopenia, inherited or acquired, can present with platelet function defects, elevating bleeding risk.
  • Existing platelet phenotyping and function assays offer diagnostic insights but often require specialized laboratory settings.
  • Many current tests are time-consuming and demand skilled personnel for sample handling and processing.

Purpose of the Study:

  • To review indications and methods for platelet phenotyping and in vitro function testing in thrombocytopenic patients.
  • To assess the clinical practicability of various diagnostic assays for platelet disorders.
  • To address the diagnostic significance, challenges, and difficulties associated with evaluating hemostatic capacity in low platelet counts.

Main Methods:

  • Literature review of established and emerging assays for platelet function analysis.
  • Evaluation of point-of-care testing feasibility for platelet disorders.
  • Analysis of diagnostic challenges in specialized laboratories for thrombocytopenic samples.

Main Results:

  • A range of tests exist for platelet phenotyping and function, with some point-of-care potential.
  • Significant challenges remain regarding test practicality, time, and personnel expertise in clinical settings.
  • Diagnostic interpretation requires careful consideration of reduced platelet numbers and specific defect evaluation.

Conclusions:

  • Effective diagnosis of platelet function defects in thrombocytopenia requires careful selection of practical assays.
  • Bridging the gap between specialized laboratory methods and clinical practicability is crucial for improved patient care.
  • Further development of user-friendly and efficient diagnostic tools is needed for timely management of bleeding complications.