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Updated: Nov 10, 2025

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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The Two-Faced Role of SIRT6 in Cancer

Francesco Fiorentino1, Vincenzo Carafa2, Gregorio Favale2

  • 1Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QZ, UK.

Cancers
|April 3, 2021
PubMed

Insights

Sirtuin 6 (SIRT6) impacts cell death and cancer by modulating apoptosis. Small molecules targeting SIRT6 offer potential new cancer therapies.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Biochemistry

Background:

  • Sirtuin 6 (SIRT6) is a nuclear deacylase and mono-ADP-ribosylase.
  • SIRT6 influences DNA repair, metabolic balance, and apoptosis, crucial for cell fate and cancer.
  • SIRT6 exhibits context-dependent roles in regulating pro- and anti-apoptotic factors.

Purpose of the Study:

  • To review the multifaceted roles of SIRT6 in cell death and cancer.
  • To discuss SIRT6's involvement in tumor initiation and progression.
  • To highlight small molecule modulators of SIRT6 for cancer research and therapeutics.

Main Methods:

  • Literature review of SIRT6 functions in apoptosis and oncogenesis.
  • Analysis of SIRT6's regulatory impact on apoptotic factors (Bax, Bcl-2, survivin).
  • Discussion of emerging small molecule SIRT6 modulators.

Main Results:

  • SIRT6's dual role in cancer, influencing apoptosis to yield opposing outcomes.
  • SIRT6's modulation of key cell death pathways.
  • Identification of small molecules as tools to study SIRT6 in cancer.

Conclusions:

  • SIRT6 plays a complex, context-dependent role in cancer biology.
  • Understanding SIRT6's regulation of apoptosis is key to cancer treatment.
  • SIRT6 modulators represent promising avenues for novel anticancer drug development.
Keywords:
NAD+-dependent deacylasesSIRT6 modulatorscancercell death modulationepigenetics

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