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Haptoglobin and Its Related Protein, Zonulin-What Is Their Role in Spondyloarthropathy?

Magdalena Chmielińska1,2, Marzena Olesińska2, Katarzyna Romanowska-Próchnicka1,2

  • 1Department of Biophysics and Human Physiology, Medical University of Warsaw, Chałubińskiego 5, 02-004 Warsaw, Poland.

Journal of Clinical Medicine
|April 3, 2021
PubMed

Haptoglobin (Hp) is an acute phase protein which supports the immune response and protects tissues from free radicals. Its concentration correlates with disease activity in spondyloarthropathies (SpAs). The Hp polymorphism determines the functional differences between Hp1 and Hp2 protein products. The role of the Hp polymorphism has been demonstrated in many diseases. In particular, the Hp 2-2 phenotype has been associated with the unfavorable course of some inflammatory and autoimmune disorders. Its potential role in modulating the immune system in SpA is still unknown. This article contains pathophysiological considerations on the potential relationship between Hp, its polymorphism and SpA.

Keywords:
haptoglobin polymorphisminflammationpathogenesisspondyloarthropathyzonulin

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